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论文题目: Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus)
第一作者: Li Muyang, Zhu Xinming, Tian Jiaxin, Liu Ming等
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发表年度: 2019
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英文摘要: The present study was conducted to evaluate the effects of dietary flavonoids from Allium mongolicum Regel (AMRF) supplementation on growth, antioxidant and immune status, immune-related genes expression and disease resistance in Channa argus. A basal diet was supplemented with AMRF at 0, 10, 20 or 40 mg/kg feed for 56 days. The result revealed that weight gain (WG) and specific growth rate (SGR) were significantly increased (P < .05) with the increase of dietary AMRF levels from 0 to 40 mg/kg. All AMRF-supplemented groups (10, 20 or 40 mg/kg) significantly enhanced (P < .05) serum AKP, lysozyme activity, C3, IgM concentration, liver antioxidant enzymes activity (SOD, CAT and GSH-Px) or decreased (P < .05) serum cortisol, liver MDA content, serum ALT and AST activity. Meanwhile, AMRF administration significantly up-regulated (P < .05) the expression of SOD, IgM, HSP70, HSP90, I kappa B-alpha and GR or down-regulated (P < .05) NF-kappa B p65 and inflammatory cytokines (TNF-alpha, IL-1 beta and IL-8) transcription in head kidney of C. argus. After challenge with Aeromonas hydrophila, survival rates in all AMRF treatment groups were significantly increased (P < .05). These results indicated that dietary intake containing AMRF enhanced growth, antioxidant and immune response and regulated immune-related genes expression and increased disease resistance against Aeromonas hydrophila in snakehead fish, with greatest effects in fish given 40 mg/kg AMRF for 56 days.
刊物名称: AQUACULTURE
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论文类别: SCI
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